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ISIS Pharma Neotone Gel is a targeted brightening and depigmenting gel specially formulated to reduce dark spots, melasma, and hyperpigmentation on the face and body. Developed by ISIS Pharma's dermatological expertise, it combines a powerful blend of brightening actives in a lightweight, fast-absorbing gel texture that penetrates quickly without leaving a greasy residue. Suitable for all skin types, it works to visibly even out skin tone, fade existing pigmentation, and prevent new dark spots from forming with regular use.
Apply ISIS Pharma Neotone Gel to clean, dry skin on the affected areas of the face and/or body. Gently massage a small amount until fully absorbed. Use morning and/or evening as part of your daily skincare routine. For best results, use consistently and always apply a broad-spectrum SPF sunscreen on exposed areas during the day, as UV exposure can worsen hyperpigmentation. Avoid contact with eyes.
Aqua/Water, Glycerin, Niacinamide, Ascorbyl Glucoside, Alpha-Arbutin, Kojic Acid, Lactic Acid, Allantoin, Panthenol, Carbomer, Sodium Hydroxide, Disodium EDTA, Tocopheryl Acetate. (Formulation may vary by batch — refer to product packaging for the most current ingredient list.)
| Brand | ISIS |
|---|---|
| Product Type | Brightening & Anti-Pigmentation Gel |
| Size | 150ml |
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

It's designed to help brighten skin and target dark spots and hyperpigmentation.
Apply to clean skin as directed on the packaging.
Yes, daily SPF is recommended alongside any brightening treatment.
Patch test first if your skin is easily irritated.
Visible changes in tone generally take consistent use over several weeks.